C2517
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C2517
Sigma
Chlordiazepoxide hydrochloride
| Synonym: | 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride |
| CAS Number: | 438-41-5 |
| Empirical Formula (Hill Notation): | C16H14ClN3O · HCl |
| Molecular Weight: | 336.22 |
| EC Number: | 207-117-8 |
| MDL number: | MFCD00069223 |
| PubChem Substance ID: | 24892497 |
Description
| Biochem/physiol Actions | Anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site. |
Properties
| drug control | USDEA Schedule IV; Home Office Schedule 4.1; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada |
Safety
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Statements | 22-62-63-68 |
| Safety Statements | 22-36/37 |
| WGK Germany | 3 |
| RTECS | DE9450000 |
References
| reference | Pereira, J.K., et al., The phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze is abolished by the introduction of a motivational conflict situation. Life Sci. 65, PL101, (1999) Abstract |
| Agmo, A. and Belzung, C., et al., The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide. Neuropharmacology 37, 223-232, (1998) Abstract | |
| Cash, D.J., et al., Desensitization of a γ-aminobutyric acid type A receptor in rat is increased by chronic treatment with chlordiazepoxide: a molecular mechanism of dependence. J. Pharmacol. Exp. Ther. 283, 704, (1997) Abstract |
